CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.79 | Nucleoside Triphosphate Pyrophosphohydrolase |
|
3.90.79.10 | Nucleoside Triphosphate Pyrophosphohydrolase |
Domain Context
CATH Clusters
| Superfamily | Nucleoside Triphosphate Pyrophosphohydrolase |
| Functional Family | mRNA-decapping enzyme 2 |
Enzyme Information
| 3.6.1.62 |
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
based on mapping to UniProt P53550
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-diphosphate + 5'-phospho-[mRNA].
-!- Decapping of mRNA is a critical step in eukaryotic mRNA turnover. -!- The enzyme is unable to cleave a free cap structure (m(7)GpppG). -!- The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+). -!- Formerly EC 3.6.1.30.
|
UniProtKB Entries (1)
| P53550 |
DCP2_YEAST
Saccharomyces cerevisiae S288C
M7GpppN-mRNA hydrolase
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PDB Structure
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| Method | |
| Organism | |
| Primary Citation |
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