CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.2300 | Response regulator |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.2300 |
| Functional Family | Arsenate reductase |
Enzyme Information
| 1.20.4.4 |
Arsenate reductase (thioredoxin).
based on mapping to UniProt P45947
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H(2)O.
-!- The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin. -!- It has no activity with glutaredoxin (cf. EC 1.20.4.1). -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds. -!- The enzyme also has the activity of EC 3.1.3.48.
|
UniProtKB Entries (1)
| P14949 |
THIO_BACSU
Bacillus subtilis subsp. subtilis str. 168
Thioredoxin
|
PDB Structure
| PDB | 2IPA |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis.
J.Biol.Chem.
|
