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1 keywords

CATH Domain 2ip1A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.620 HUPs

Domain Context

CATH Clusters

Superfamily HUPs
Functional Family tryptophan--tRNA ligase, cytoplasmic

Enzyme Information

6.1.1.2
Tryptophan--tRNA ligase.
based on mapping to UniProt Q12109
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl- tRNA(Trp).

UniProtKB Entries (1)

Q12109
SYWC_YEAST
Saccharomyces cerevisiae S288C
Tryptophan--tRNA ligase, cytoplasmic

PDB Structure

PDB 2IP1
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing.
Malkowski, M.G., Quartley, E., Friedman, A.E., Babulski, J., Kon, Y., Wolfley, J., Said, M., Luft, J.R., Phizicky, E.M., DeTitta, G.T., Grayhack, E.J.
Proc.Natl.Acad.Sci.Usa
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