CATH Domain 2i82D00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.2350	Pseudouridine synthase
	3.30.2350.10	Pseudouridine synthase

Domain Context

CATH Clusters

Superfamily	Pseudouridine synthase
Functional Family	Pseudouridine synthase

Enzyme Information

5.4.99.29	23S rRNA pseudouridine(746) synthase. based on mapping to UniProt P0AA37 23S rRNA uridine(746) = 23S rRNA pseudouridine(746). -!- RluA is the sole protein responsible for the in vivo formation of 23S RNA pseudouridine(746). -!- The dual-specificity enzyme also catalyzes the formation of uridine(32) in tRNA. -!- Cf. EC 5.4.99.28.
5.4.99.28	tRNA pseudouridine(32) synthase. based on mapping to UniProt P0AA37 tRNA uridine(32) = tRNA pseudouridine(32). -!- The dual-specificity enzyme also catalyzes the formation of pseudouridine(746) in 23S rRNA. -!- Cf. EC 5.4.99.29.

UniProtKB Entries (1)

RLUA_ECOLI

Escherichia coli K-12

Ribosomal large subunit pseudouridine synthase A

PDB Structure

PDB	2I82
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure Hoang, C., Chen, J., Vizthum, C.A., Kandel, J.M., Hamilton, C.S., Mueller, E.G., Ferre-D'Amare, A.R. Mol.Cell