CATH Domain 2hrmA00

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.40	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A
	2.70.40.10	Deoxyuridine triphosphatase (dUTPase)

Domain Context

CATH Clusters

Superfamily	2.70.40.10
Functional Family	dUTP diphosphatase

Enzyme Information

3.6.1.23

dUTP diphosphatase.

based on mapping to UniProt P06968

dUTP + H(2)O = dUMP + diphosphate.

UniProtKB Entries (1)

DUT_ECOLI

Escherichia coli K-12

Deoxyuridine 5'-triphosphate nucleotidohydrolase

PDB Structure

PDB	2HRM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Kovari, J., Barabas, O., Varga, B., Bekesi, A., Tolgyesi, F., Fidy, J., Nagy, J., Vertessy, B.G. Proteins