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1 keywords

CATH Domain 2gk1J02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.80 Glycosidases

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Beta-hexosaminidase A

Enzyme Information

3.2.1.52
Beta-N-acetylhexosaminidase.
based on mapping to UniProt P06865
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
-!- Acts on N-acetylglucosides and N-acetylgalactosides. -!- Formerly EC 3.2.1.29 and EC 3.2.1.30.

UniProtKB Entries (1)

P07686
HEXB_HUMAN
Homo sapiens
Beta-hexosaminidase subunit beta

PDB Structure

PDB 2GK1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis.
Lemieux, M.J., Mark, B.L., Cherney, M.M., Withers, S.G., Mahuran, D.J., James, M.N.
J.Mol.Biol.
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