CATH Domain 2ftpA00

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Hydroxymethylglutaryl-CoA lyase

Enzyme Information

4.1.3.26	3-hydroxy-3-isohexenylglutaryl-CoA lyase. based on mapping to UniProt Q9I2A0 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6- enoyl-CoA + acetate. -!- Also acts on the hydroxy derivative of farnesoyl-CoA.
4.1.3.4	Hydroxymethylglutaryl-CoA lyase. based on mapping to UniProt Q9I2A0 (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.

UniProtKB Entries (1)

LIUE_PSEAE

Pseudomonas aeruginosa PAO1

3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase

PDB Structure

PDB	2FTP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa Xiao, T., Evdokimova, E., Liu, Y., Kudritska, M., Savchenko, A., Pai, E.F., Edwards, A. To be Published