CATH Domain 2ftdB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38

Cathepsin K.

based on mapping to UniProt P61277

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P61277

CATK_MACMU

Macaca mulatta

Cathepsin K

PDB Structure

PDB	2FTD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. Yamashita, D.S., Marquis, R.W., Xie, R., Nidamarthy, S.D., Oh, H.J., Jeong, J.U., Erhard, K.F., Ward, K.W., Roethke, T.J., Smith, B.R., Cheng, H.Y., Geng, X., Lin, F., Offen, P.H., Wang, B., Nevins, N., Head, M.S., Haltiwanger, R.C., Narducci Sarjeant, A.A., Liable-Sands, L.M., Zhao, B., Smith, W.W., Janson, C.A., Gao, E., Tomaszek, T., McQueney, M., James, I.E., Gress, C.J., Zembryki, D.L., Lark, M.W., Veber, D.F. J.Med.Chem.

Network disruptions