CATH Domain 2fjuB01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.240

Domain Context

CATH Clusters

Superfamily	2.30.29.240
Functional Family	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Enzyme Information

3.1.4.11

Phosphoinositide phospholipase C.

based on mapping to UniProt Q00722

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

P63000

RAC1_HUMAN

Homo sapiens

Ras-related C3 botulinum toxin substrate 1

PDB Structure

PDB	2FJU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Jezyk, M.R., Snyder, J.T., Gershberg, S., Worthylake, D.K., Harden, T.K., Sondek, J. Nat.Struct.Mol.Biol.