CATH Domain 2fbwC02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1300	3 helical TM bundles of succinate and fumarate reductases
	1.20.1300.10	Fumarate reductase/succinate dehydrogenase, transmembrane subunit

Domain Context

CATH Clusters

Superfamily	Fumarate reductase/succinate dehydrogenase, transmembrane subunit
Functional Family	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Enzyme Information

UniProtKB Entries (1)

D0VWW3_CHICK

Gallus gallus

Succinate dehydrogenase cytochrome b, large subunit

PDB Structure

PDB	2FBW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. Huang, L.S., Sun, G., Cobessi, D., Wang, A.C., Shen, J.T., Tung, E.Y., Anderson, V.E., Berry, E.A. J.Biol.Chem.