CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.80 | HRDC domain |
Domain Context
CATH Clusters
| Superfamily | HRDC domain |
| Functional Family | Werner syndrome ATP-dependent helicase homolog |
Enzyme Information
| 3.6.4.12 |
DNA helicase.
based on mapping to UniProt Q14191
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
|
| 3.1.-.- |
Acting on ester bonds.
based on mapping to UniProt Q14191
|
UniProtKB Entries (1)
| Q14191 |
WRN_HUMAN
Homo sapiens
Werner syndrome ATP-dependent helicase
|
PDB Structure
| PDB | 2E1F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the HRDC domain of human Werner syndrome protein, WRN
J.Biol.Chem.
|
