CATH Domain 2blnA02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.25	Methionyl-tRNA Fmet Formyltransferase; Chain A, domain 2
	3.10.25.10	Formyl transferase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Formyl transferase, C-terminal domain
Functional Family

Enzyme Information

1.1.1.305	UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating). based on mapping to UniProt P77398 UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L-threo-pentapyranos-4-ulose + CO(2) + NADH. -!- The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13. -!- Formerly EC 1.1.1.n1.
2.1.2.13	UDP-4-amino-4-deoxy-L-arabinose formyltransferase. based on mapping to UniProt P77398 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinose. -!- The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305. -!- Formerly EC 2.1.2.n1.

UniProtKB Entries (1)

ARNA_ECOLI

Escherichia coli K-12

Bifunctional polymyxin resistance protein ArnA

PDB Structure

PDB	2BLN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and Function of Both Domains of Arna, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-Deoxy-L-Arabinose Biosynthesis. Williams, G.J., Breazeale, S.D., Raetz, C.R.H., Naismith, J.H. J.Biol.Chem.