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1 keywords

CATH Domain 2bktB01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.70 Cathepsin D, subunit A; domain 1
Homologous Superfamily 2.40.70.10 Acid Proteases

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family renin

Enzyme Information

3.4.23.15
Renin.
based on mapping to UniProt P00797
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

UniProtKB Entries (1)

P00797
RENI_HUMAN
Homo sapiens
Renin

PDB Structure

PDB 2BKT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Equipotent Activity in Both Enantiomers of a Series of Ketopiperazine-Based Renin Inhibitors
Powell, N.A., Clay, E.H., Holsworth, D.D., Bryant, J.W., Ryan, J.M., Jalaie, M., Zhang, E., Edmunds, J.J.
Bioorg.Med.Chem.Lett.
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