CATH Domain 2ag5D00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	3-hydroxybutyrate dehydrogenase type 2

Enzyme Information

1.1.1.-	With NAD(+) or NADP(+) as acceptor. based on mapping to UniProt Q9BUT1
1.1.1.30	3-hydroxybutyrate dehydrogenase. based on mapping to UniProt Q9BUT1 (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH. -!- Also oxidizes other 3-hydroxymonocarboxylic acids.

UniProtKB Entries (1)

BDH2_HUMAN

Homo sapiens

3-hydroxybutyrate dehydrogenase type 2

PDB Structure

PDB	2AG5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase Guo, K., Lukacik, P., Papagrigoriou, E., Meier, M., Lee, W.H., Adamski, J., Oppermann, U. J.Biol.Chem.