CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Thiazole biosynthesis adenylyltransferase ThiF |
Enzyme Information
| 2.7.7.73 |
Sulfur carrier protein ThiS adenylyltransferase.
based on mapping to UniProt P30138
ATP + [ThiS] = diphosphate + adenylyl-[ThiS].
-!- The enzyme catalyzes the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine. -!- The enzyme shows significant structural similarity to ubiquitin- activating enzyme. -!- In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide. -!- Formerly EC 2.7.7.n3.
|
UniProtKB Entries (1)
| O32583 |
THIS_ECOLI
Escherichia coli K-12
Sulfur carrier protein ThiS
|
PDB Structure
| PDB | 1ZUD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of the Escherichia coli ThiS-ThiF Complex, a Key Component of the Sulfur Transfer System in Thiamin Biosynthesis.
Biochemistry
|
