CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family

Enzyme Information

3.4.21.110
C5a peptidase.
based on mapping to UniProt P15926
The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59.
-!- Surface-associated subtilisin-like serine peptidase with very specific substrate specificity. -!- Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a. -!- Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties. -!- Belongs to peptidase family S8A.

UniProtKB Entries (1)

P15926
C5AP_STRPY
Streptococcus pyogenes
C5a peptidase

PDB Structure

PDB
External Links
Method
Organism
Primary Citation
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