CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.309 | Aldehyde Dehydrogenase; Chain A, domain 2 |
|
3.40.309.10 | Aldehyde Dehydrogenase; Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Aldehyde Dehydrogenase; Chain A, domain 2 |
| Functional Family | Gamma-aminobutyraldehyde dehydrogenase |
Enzyme Information
| 1.2.1.19 |
Aminobutyraldehyde dehydrogenase.
based on mapping to UniProt P77674
4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH.
-!- The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates. -!- The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54). -!- As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. -!- Formerly EC 1.5.1.35.
|
UniProtKB Entries (1)
| P77674 |
ABDH_ECOLI
Escherichia coli K-12
Gamma-aminobutyraldehyde dehydrogenase
|
PDB Structure
| PDB | 1WND |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure and Kinetics Identify Escherichia coli YdcW Gene Product as a Medium-chain Aldehyde Dehydrogenase
J.Mol.Biol.
|
