CATH Domain 1v04A00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.30	TolB, C-terminal domain

Domain Context

CATH Clusters

Superfamily	TolB, C-terminal domain
Functional Family	Serum paraoxonase/arylesterase 2

Enzyme Information

3.1.8.1	Aryldialkylphosphatase. based on mapping to UniProt P27170 An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol. -!- Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. -!- Inhibited by chelating agents. -!- Previously regarded as identical with EC 3.1.1.2.
3.1.1.81	Quorum-quenching N-acyl-homoserine lactonase. based on mapping to UniProt P27170 An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine. -!- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. -!- Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes. -!- Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria. -!- N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
3.1.1.2	Arylesterase. based on mapping to UniProt P27170 A phenyl acetate + H(2)O = a phenol + acetate. -!- Acts on many phenolic esters. -!- It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases. -!- The natural substrates of the paraoxonases are lactones, with (+-)-5- hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate.

UniProtKB Entries (1)

PON1_RABIT

Oryctolagus cuniculus

Serum paraoxonase/arylesterase 1

PDB Structure

PDB	1V04
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and Evolution of the Serum Paraoxonase Family of Detoxifying and Anti-Atherosclerotic Enzymes Harel, M., Aharoni, A., Gaidukov, L., Brumshtein, B., Khersonsky, O., Meged, R., Dvir, H., Ravelli, R.B.G., Mccarthy, A., Toker, L., Silman, I., Sussman, J.L., Tawfik, D.S. Nat.Struct.Mol.Biol.