CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.3140 | 4-hydroxybutyryl-coa dehydratase, domain 1 |
|
1.10.3140.10 | 4-hydroxybutyryl-coa dehydratase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | 4-hydroxybutyryl-coa dehydratase, domain 1 |
| Functional Family |
Enzyme Information
| 4.2.1.120 |
4-hydroxybutanoyl-CoA dehydratase.
based on mapping to UniProt P55792
4-hydroxybutanoyl-CoA = (E)-but-2-enoyl-CoA + H(2)O.
-!- The enzyme has been characterized from several microorganisms, including Clostridium kluyveri, where it participates in succinate fermentation, Clostridium aminobutyricum, where it participates in 4-aminobutyrate degradation, and Metallosphaera sedula, where it participates in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
|
| 5.3.3.3 |
Vinylacetyl-CoA Delta-isomerase.
based on mapping to UniProt P55792
Vinylacetyl-CoA = (E)-but-2-enoyl-CoA.
-!- Also acts on 3-methyl-vinylacetyl-CoA.
|
UniProtKB Entries (1)
| P55792 |
HDVD_CLOAM
Clostridium aminobutyricum
4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase
|
PDB Structure
| PDB | 1U8V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of 4-hydroxybutyryl-CoA dehydratase: radical catalysis involving a [4Fe-4S] cluster and flavin.
Proc.Natl.Acad.Sci.USA
|
