CATH Domain 1tvvA00

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P00469

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_LACCA

Lactobacillus casei

Thymidylate synthase

PDB Structure

PDB	1TVV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase. Finer-Moore, J.S., Liu, L., Birdsall, D.L., Brem, R., Apfeld, J., Santi, D.V., Stroud, R.M. J.Mol.Biol.