CATH Domain 1t0iB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.360	Flavodoxin domain

Domain Context

CATH Clusters

Superfamily	3.40.50.360
Functional Family	NAD(P)H-dependent FMN reductase LOT6

Enzyme Information

1.5.1.39

FMN reductase (NAD(P)H).

based on mapping to UniProt Q07923

FMNH(2) + NAD(P)(+) = FMN + NAD(P)H.

-!- The enzyme can utilize NADH and NADPH with similar reaction rates. -!- Different from EC 1.5.1.42 and EC 1.5.1.38. -!- The luminescent bacterium Vibrio harveyi possesses all three enzymes, while the bacterium Aliivibrio fischeri contains only this non- specific type. -!- Also reduces riboflavin and FAD, but more slowly. -!- Formerly EC 1.5.1.29 and EC 1.6.8.1.

UniProtKB Entries (1)

Q07923

LOT6_YEAST

Saccharomyces cerevisiae S288C

NAD(P)H-dependent FMN reductase LOT6

PDB Structure

PDB	1T0I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure and Functional Characterization of Yeast YLR011wp, an Enzyme with NAD(P)H-FMN and Ferric Iron Reductase Activities Liger, D., Graille, M., Zhou, C.-Z., Leulliot, N., Quevillon-Cheruel, S., Blondeau, K., Janin, J., Van Tilbeurgh, H. J.Biol.Chem.