CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.630 | Aminopeptidase |
|
3.40.630.30 | Gcn5-related N-acetyltransferase (GNAT) |
Domain Context
CATH Clusters
| Superfamily | 3.40.630.30 |
| Functional Family | Aminoglycoside N(6')-acetyltransferase type 1 |
Enzyme Information
| 2.3.1.82 |
Aminoglycoside 6'-N-acetyltransferase.
based on mapping to UniProt Q9R381
Acetyl-CoA + kanamycin-B = CoA + N(6')-acetylkanamycin-B.
-!- The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C(1a), gentamicin C(2), sisomicin and tobramycin are substrates. -!- The antibiotic paromomycin is not a substrate. -!- The 6-amino group of the purpurosamine ring is acetylated. -!- Formerly EC 2.3.1.55.
|
UniProtKB Entries (1)
| Q9R381 |
AAC6_SALEN
Salmonella enterica subsp. enterica serovar Enteritidis
Aminoglycoside N(6')-acetyltransferase type 1
|
PDB Structure
| PDB | 1S3Z |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
Chem.Biol.
|
