CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1100 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1100 |
| Functional Family | 1-aminocyclopropane-1-carboxylate deaminase |
Enzyme Information
| 3.5.99.7 |
1-aminocyclopropane-1-carboxylate deaminase.
based on mapping to UniProt Q00740
1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanoate + NH(3).
-!- The enzyme, found in certain soil bacteria and fungi, catalyzes the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes. -!- The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes spontaneous hydrolytic deamination. -!- The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation. -!- Formerly EC 4.1.99.4.
|
UniProtKB Entries (1)
| Q00740 |
1A1D_PSEUD
Pseudomonas sp. ACP
1-aminocyclopropane-1-carboxylate deaminase
|
PDB Structure
| PDB | 1RQX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural analysis of 1-aminocyclopropane-1-carboxylate deaminase: observation of an aminyl intermediate and identification of Tyr 294 as the active-site nucleophile.
Angew.Chem.Int.Ed.Engl.
|
