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1 keywords

CATH Domain 1rfnB00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.10 Ribbon
Topology 2.10.25 Laminin
Homologous Superfamily 2.10.25.10 Laminin

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Coagulation factor VII

Enzyme Information

3.4.21.22
Coagulation factor IXa.
based on mapping to UniProt P00740
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- The proenzyme factor IX is activated by EC 3.4.21.27. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00740
FA9_HUMAN
Homo sapiens
Coagulation factor IX

PDB Structure

PDB 1RFN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.
Hopfner, K.P., Lang, A., Karcher, A., Sichler, K., Kopetzki, E., Brandstetter, H., Huber, R., Bode, W., Engh, R.A.
Structure Fold.Des.
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