CATH Domain 1rbzA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.170	Formyl transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Formyl transferase, N-terminal domain
Functional Family	Trifunctional purine biosynthetic protein adenosine-3

Enzyme Information

2.1.2.2	Phosphoribosylglycinamide formyltransferase. based on mapping to UniProt P22102 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
6.3.4.13	Phosphoribosylamine--glycine ligase. based on mapping to UniProt P22102 ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide. -!- Formerly EC 6.3.1.3.
6.3.3.1	Phosphoribosylformylglycinamidine cyclo-ligase. based on mapping to UniProt P22102 ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

UniProtKB Entries (1)

PUR2_HUMAN

Homo sapiens

Trifunctional purine biosynthetic protein adenosine-3

PDB Structure

PDB	1RBZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Human GAR Tfase complex structure Zhang, Y., Desharnais, J., Boger, D.L., Wilson, I.A. To be Published