CATH Domain 1qxpB02

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Calpain-1 catalytic subunit

Enzyme Information

3.4.22.52	Calpain-1. based on mapping to UniProt P97571 Broad endopeptidase specificity. -!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.
3.4.22.53	Calpain-2. based on mapping to UniProt Q07009 Broad endopeptidase specificity. -!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.

UniProtKB Entries (1)

CPNS1_RAT

Rattus norvegicus

Calpain small subunit 1

PDB Structure

PDB	1QXP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of a mu-like calpain reveals a partially activated conformation with low Ca(2+) requirement Pal, G.P., Veyra, T.D., Elce, J.S., Jia, Z. Structure