CATH Domain 1pl2B01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.30	Glutaredoxin
	3.40.30.10	Glutaredoxin

Domain Context

CATH Clusters

Superfamily	Glutaredoxin
Functional Family

Enzyme Information

2.5.1.18	Glutathione transferase. based on mapping to UniProt P08263 RX + glutathione = HX + R-S-glutathione. -!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
1.11.1.-	Peroxidases. based on mapping to UniProt P08263
5.3.3.-	Transposing C=C bonds. based on mapping to UniProt P08263

UniProtKB Entries (1)

GSTA1_HUMAN

Homo sapiens

Glutathione S-transferase A1

PDB Structure

PDB	1PL2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix. Grahn, E., Novotny, M., Jakobsson, E., Gustafsson, A., Grehn, L., Olin, B., Madsen, D., Wahlberg, M., Mannervik, B., Kleywegt, G.J. Acta Crystallogr.,Sect.D