CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.226 | 2-enoyl-CoA Hydratase; Chain A, domain 1 |
|
3.90.226.10 | 2-enoyl-CoA Hydratase; Chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | 2-enoyl-CoA Hydratase; Chain A, domain 1 |
| Functional Family | 6-oxocamphor hydrolase |
Enzyme Information
| 3.7.1.18 |
6-oxocamphor hydrolase.
based on mapping to UniProt Q93TU6
Bornane-2,6-dione + H(2)O = ((1S)-4-hydroxy-2,2,3-trimethylcyclopent-3- enyl)acetate.
-!- Isolated from Rhodococcus sp. -!- The bornane ring system is cleaved by a retro-Claisen reaction to give the enol of alpha-campholonate. -!- When separate from the enzyme the enol is tautomerised to the keto form as a 6:1 mixture of ((1S,3R)-2,2,3-trimethyl-4- oxocyclopentyl)acetate and ((1S,3S)-2,2,3-trimethyl-4- oxocyclopentyl)acetate.
|
UniProtKB Entries (1)
| Q93TU6 |
CAMK_RHOSO
Rhodococcus sp.
6-oxocamphor hydrolase
|
PDB Structure
| PDB | 1O8U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The 2 a Crystal Structure of 6-Oxo Camphor Hydrolase: New Structural Diversity in the Crotonase Superfamily
J.Biol.Chem.
|
