CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Quinone oxidoreductase YhdH |
Enzyme Information
| 1.3.1.84 |
Acrylyl-CoA reductase (NADPH).
based on mapping to UniProt P26646
Propanoyl-CoA + NADP(+) = acrylyl-CoA + NADPH.
-!- Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea. -!- The reaction is catalyzed in the opposite direction to that shown. -!- The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA. -!- Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16.
|
UniProtKB Entries (1)
| P26646 |
ACUI_ECOLI
Escherichia coli K-12
Probable acrylyl-CoA reductase AcuI
|
PDB Structure
| PDB | 1O8C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Escherichia Coli Yhdh, a Putative Quinone Oxidoreductase
Acta Crystallogr.,Sect.D
|
