CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1520 | Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
|
1.10.1520.10 | Ribonuclease III domain |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease III domain |
| Functional Family | Ribonuclease 3 |
Enzyme Information
| 3.1.26.3 |
Ribonuclease III.
based on mapping to UniProt Q9X0I6
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.
|
UniProtKB Entries (1)
| Q9X0I6 |
RNC_THEMA
Thermotoga maritima MSB8
Ribonuclease 3
|
PDB Structure
| PDB | 1O0W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of Ribonuclease III (TM1102) from Thermotoga maritima at 2.0 A resolution
To be published
|
