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1 keywords

CATH Domain 1n7iA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Phenylethanolamine N-methyltransferase

Enzyme Information

2.1.1.28
Phenylethanolamine N-methyltransferase.
based on mapping to UniProt P11086
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
-!- Acts on various phenylethanolamines; converts noradrenaline into adrenaline.

UniProtKB Entries (1)

P11086
PNMT_HUMAN
Homo sapiens
Phenylethanolamine N-methyltransferase

PDB Structure

PDB 1N7I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
McMillan, F.M., Archbold, J., McLeish, M.J., Caine, J.M., Criscione, K.R., Grunewald, G.L., Martin, J.L.
J.Med.Chem.
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