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1 keywords

CATH Domain 1n28B00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.90 Phospholipase A2
Homologous Superfamily 1.20.90.10 Phospholipase A2 domain

Domain Context

CATH Clusters

Superfamily Phospholipase A2 domain
Functional Family Basic phospholipase A2 homolog

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt P14555
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.

UniProtKB Entries (1)

P14555
PA2GA_HUMAN
Homo sapiens
Phospholipase A2, membrane associated

PDB Structure

PDB 1N28
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism
Edwards, S.H., Thompson, D., Baker, S.F., Wood, S.P., Wilton, D.C.
Biochemistry
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