CATH Domain 1mrsA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidylate kinase

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt P9WKE1

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_MYCTU

Mycobacterium tuberculosis H37Rv

Thymidylate kinase

PDB Structure

PDB	1MRS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism. Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M. J.Biol.Chem.