CATH Domain 1k2wB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Sorbitol dehydrogenase

Enzyme Information

1.1.1.14	L-iditol 2-dehydrogenase. based on mapping to UniProt Q59787 L-iditol + NAD(+) = L-sorbose + NADH. -!- This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. -!- It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. -!- Enzymes from different organisms or tissues display different substrate specificity. -!- The enzyme is specific to NAD(+) and can not use NADP(+).
1.1.1.-	With NAD(+) or NADP(+) as acceptor. based on mapping to UniProt Q59787
1.1.1.16	Galactitol 2-dehydrogenase. based on mapping to UniProt Q59787 Galactitol + NAD(+) = D-tagatose + NADH. -!- Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. -!- The enzyme from Agrobacterium rubrum C58 is part of D-altritol and galactitol degradation pathways.

UniProtKB Entries (1)

SDH_RHOSH

Rhodobacter sphaeroides

Sorbitol dehydrogenase

PDB Structure

PDB	1K2W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution. Philippsen, A., Schirmer, T., Stein, M.A., Giffhorn, F., Stetefeld, J. Acta Crystallogr.,Sect.D