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1 keywords

CATH Domain 1jr1B00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

1.1.1.205
IMP dehydrogenase.
based on mapping to UniProt P12269
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
-!- The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. -!- Formerly EC 1.2.1.14.

UniProtKB Entries (1)

P12269
IMDH2_CRIGR
Cricetulus griseus
Inosine-5'-monophosphate dehydrogenase 2

PDB Structure

PDB 1JR1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
Sintchak, M.D., Fleming, M.A., Futer, O., Raybuck, S.A., Chambers, S.P., Caron, P.R., Murcko, M.A., Wilson, K.P.
Cell(Cambridge,Mass.)
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