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1 keywords

CATH Domain 1jheA00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.10 Ribbon
Topology 2.10.109 Umud Fragment, subunit A
Homologous Superfamily 2.10.109.10 Umud Fragment, subunit A

Domain Context

CATH Clusters

Superfamily Umud Fragment, subunit A
Functional Family LexA repressor

Enzyme Information

3.4.21.88
Repressor LexA.
based on mapping to UniProt P0A7C2
Hydrolysis of Ala-|-Gly bond in repressor LexA.
-!- In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. -!- The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37). -!- Belongs to peptidase family S24.

UniProtKB Entries (1)

P0A7C2
LEXA_ECOLI
Escherichia coli K-12
LexA repressor

PDB Structure

PDB 1JHE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of LexA: a conformational switch for regulation of self-cleavage.
Luo, Y., Pfuetzner, R.A., Mosimann, S., Paetzel, M., Frey, E.A., Cherney, M., Kim, B., Little, J.W., Strynadka, N.C.
Cell(Cambridge,Mass.)
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