CATH Domain 1idtA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.109	NADH Oxidase
	3.40.109.10	NADH Oxidase

Domain Context

CATH Clusters

Superfamily	NADH Oxidase
Functional Family	Oxygen-insensitive NAD(P)H nitroreductase

Enzyme Information

1.5.1.34	6,7-dihydropteridine reductase. based on mapping to UniProt P38489 A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H. -!- The substrate is the quinonoid form of dihydropteridine. -!- Not identical with EC 1.5.1.3. -!- Formerly EC 1.6.99.7 and EC 1.6.99.10.
1.-.-.-	Oxidoreductases. based on mapping to UniProt P38489

UniProtKB Entries (1)

NFSB_ECOLI

Escherichia coli K-12

Oxygen-insensitive NAD(P)H nitroreductase

PDB Structure

PDB	1IDT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form. Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S. J.Med.Chem.