CATH Domain 1gszC02

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.50	Alpha/alpha barrel
	1.50.10	Glycosyltransferase
	1.50.10.20

Domain Context

CATH Clusters

Superfamily	1.50.10.20
Functional Family

Enzyme Information

5.4.99.17	Squalene--hopene cyclase. based on mapping to UniProt P33247 Squalene = hop-22(29)-ene. -!- The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129). -!- Hopene and hopanol are formed at a constant ratio of 5:1.
4.2.1.129	Squalene--hopanol cyclase. based on mapping to UniProt P33247 Hopan-22-ol = squalene + H(2)O. -!- The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.

UniProtKB Entries (1)

SQHC_ALIAD

Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446

Squalene--hopene cyclase

PDB Structure

PDB	1GSZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071 Lenhart, A., Weihofen, W.A., Pleschke, A.E.W., Schulz, G.E. Chem.Biol.