CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.1.1.50 |
3-alpha-hydroxysteroid 3-dehydrogenase (Si-specific).
based on mapping to UniProt P80702
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on androsterone and other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. -!- Si-specific with respect to NAD(+) or NADP(+) (cf. EC 1.1.1.213).
|
UniProtKB Entries (1)
| P80702 |
DIDH_COMTE
Comamonas testosteroni
3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase
|
PDB Structure
| PDB | 1FK8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family.
J.Biol.Chem.
|
