CATH Domain 1f7zA01

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Anionic trypsin-2

Enzyme Information

3.4.21.4

Trypsin.

based on mapping to UniProt P00763

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (2)

P00763	TRY2_RAT Rattus norvegicus Anionic trypsin-2
P00974	BPT1_BOVIN Bos taurus Pancreatic trypsin inhibitor

PDB Structure

PDB	1F7Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Saccharomyces
Primary Citation	The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity. Pasternak, A., White, A., Jeffery, C.J., Medina, N., Cahoon, M., Ringe, D., Hedstrom, L. Protein Sci.