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1 keywords

CATH Domain 1f4dB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.572 Thymidylate Synthase; Chain A
Homologous Superfamily 3.30.572.10 Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P0A884
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P0A884
TYSY_ECOLI
Escherichia coli K-12
Thymidylate synthase

PDB Structure

PDB 1F4D
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Site-directed ligand discovery.
Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E.M., Wells, J.A.
Proc.Natl.Acad.Sci.USA
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