CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.196 |
Cobalt-precorrin-6B (C(15))-methyltransferase (decarboxylating).
based on mapping to UniProt O26249
Cobalt-precorrin-6B + S-adenosyl-L-methionine = cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO(2).
-!- This enzyme catalyzes both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-6B, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway.
|
UniProtKB Entries (1)
| O26249 |
CBIT_METTH
Methanothermobacter thermautotrophicus str. Delta H
Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)
|
PDB Structure
| PDB | 1F38 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w
decarboxylase is a methyltransferase
Structure
|
