CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.2300 | Response regulator |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.2300 |
| Functional Family | Protein-glutamate methylesterase/protein-glutamine glutaminase |
Enzyme Information
| 3.1.1.61 |
Protein-glutamate methylesterase.
based on mapping to UniProt P04042
Protein L-glutamate O(5)-methyl ester + H(2)O = protein L-glutamate + methanol.
-!- Hydrolyzes the products of EC 2.1.1.77, EC 2.1.1.78, EC 2.1.1.80 and EC 2.1.1.100.
|
| 3.5.1.44 |
Protein-glutamine glutaminase.
based on mapping to UniProt P04042
Protein L-glutamine + H(2)O = protein L-glutamate + NH(3).
-!- Specific for the hydrolysis of the gamma-amide of glutamine substituted at the carboxyl position or both the alpha-amino and carboxyl positions, e.g., L-glutaminylglycine and L-phenylalanyl-L- glutaminylglycine.
|
UniProtKB Entries (1)
| P04042 |
CHEB_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Protein-glutamate methylesterase/protein-glutamine glutaminase
|
PDB Structure
| PDB | 1A2O |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for methylesterase CheB regulation by a phosphorylation-activated domain.
Proc.Natl.Acad.Sci.USA
|
