The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 74: Transcription factor ORG2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
12 A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) Q9FYE6 (/ISS) Q9M1K0 (/ISS) Q9M1K1 (/ISS) Q9ZVB5 (/ISS)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q9FYE6 (/IPI) Q9M1K0 (/IPI) Q9M1K1 (/IPI) Q9ZVB5 (/IPI) Q9ZVB5 (/IPI) Q9ZVB5 (/IPI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q0JFZ0 (/IDA)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
6 A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
6 Q9FYE6 (/TAS) Q9M1K0 (/TAS) Q9M1K1 (/TAS) Q9ZVB5 (/TAS) Q9ZVB5 (/TAS) Q9ZVB5 (/TAS)
Cellular response to iron ion starvation GO:0010106
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
6 Q9FYE6 (/IEP) Q9M1K0 (/IEP) Q9M1K1 (/IEP) Q9ZVB5 (/IEP) Q9ZVB5 (/IEP) Q9ZVB5 (/IEP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
6 A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
6 Q9FYE6 (/IGI) Q9M1K0 (/IGI) Q9M1K1 (/IGI) Q9ZVB5 (/IGI) Q9ZVB5 (/IGI) Q9ZVB5 (/IGI)
Response to iron ion starvation GO:1990641
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.
6 A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS) A2WZ60 (/ISS)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
3 Q9ZVB5 (/IEP) Q9ZVB5 (/IEP) Q9ZVB5 (/IEP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q0JFZ0 (/IDA)
Response to ethylene GO:0009723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus.
1 Q0JFZ0 (/IEP)
Regulation of ethylene-activated signaling pathway GO:0010104
Any process that modulates the frequency, rate or extent of ethylene (ethene) signal transduction.
1 Q0JFZ0 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q0JFZ0 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q0JFZ0 (/IMP)
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
1 Q0JFZ0 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q0JFZ0 (/IEP)
Response to nitric oxide GO:0071731
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
1 Q0JFZ0 (/IEP)
Positive regulation of siderophore biosynthetic process GO:1900706
Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process.
1 Q0JFZ0 (/IMP)
Response to iron ion starvation GO:1990641
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.
1 Q0JFZ0 (/IEP)
Response to iron ion starvation GO:1990641
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.
1 Q0JFZ0 (/IMP)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.