The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 45: upstream stimulatory factor 2 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 24 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | Q15853 (/IPI) Q15853 (/IPI) Q15853 (/IPI) Q64705 (/IPI) Q64705 (/IPI) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
5 | Q15853 (/IDA) Q15853 (/IDA) Q15853 (/IDA) Q63665 (/IDA) Q63665 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | Q15853 (/IMP) Q15853 (/IMP) Q15853 (/IMP) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | Q15853 (/ISA) Q15853 (/ISA) Q15853 (/ISA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | Q15853 (/ISM) Q15853 (/ISM) Q15853 (/ISM) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | Q15853 (/NAS) Q15853 (/NAS) Q15853 (/NAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
3 | Q15853 (/TAS) Q15853 (/TAS) Q15853 (/TAS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | Q15853 (/IPI) Q15853 (/IPI) Q15853 (/IPI) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
3 | Q15853 (/IPI) Q15853 (/IPI) Q15853 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | Q15853 (/IPI) Q15853 (/IPI) Q15853 (/IPI) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | Q63665 (/IDA) Q63665 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q64705 (/IDA) Q64705 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
2 | Q63665 (/IDA) Q63665 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | Q63665 (/IMP) Q63665 (/IMP) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q63665 (/IMP) Q63665 (/IMP) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q63665 (/IMP) Q63665 (/IMP) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription from RNA polymerase II promoter by glucose GO:0000432
Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.
|
5 | Q15853 (/IMP) Q15853 (/IMP) Q15853 (/IMP) Q64705 (/IMP) Q64705 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | Q15853 (/IMP) Q15853 (/IMP) Q15853 (/IMP) Q63665 (/IMP) Q63665 (/IMP) |
|
Regulation of transcription from RNA polymerase II promoter by glucose GO:0000430
Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q15853 (/IC) Q15853 (/IC) Q15853 (/IC) |
|
Positive regulation of transcription from RNA polymerase II promoter by glucose GO:0000432
Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.
|
3 | Q15853 (/ISS) Q15853 (/ISS) Q15853 (/ISS) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
3 | Q15853 (/IMP) Q15853 (/IMP) Q15853 (/IMP) |
|
Late viral transcription GO:0019086
The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins.
|
3 | Q15853 (/IC) Q15853 (/IC) Q15853 (/IC) |
|
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
|
3 | Q15853 (/ISS) Q15853 (/ISS) Q15853 (/ISS) |
|
Positive regulation of transcription from RNA polymerase II promoter by glucose GO:0000432
Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q64705 (/IDA) Q64705 (/IDA) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
|
2 | Q64705 (/IMP) Q64705 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q64705 (/IDA) Q64705 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
|
2 | Q64705 (/IMP) Q64705 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | Q15853 (/IDA) Q15853 (/IDA) Q15853 (/IDA) Q63665 (/IDA) Q63665 (/IDA) Q64705 (/IDA) Q64705 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
6 | B4DLJ1 (/IDA) B4DLJ1 (/IDA) E9PME6 (/IDA) Q15853 (/IDA) Q15853 (/IDA) Q15853 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
5 | B4DLJ1 (/IDA) B4DLJ1 (/IDA) Q15853 (/IDA) Q15853 (/IDA) Q15853 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q15853 (/TAS) Q15853 (/TAS) Q15853 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | Q64705 (/ISO) Q64705 (/ISO) |