The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Creatinase/methionine aminopeptidase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Xaa-Pro aminopeptidase 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
17 Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS)
(7 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 P12955 (/IPI) P12955 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI)
(6 more)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
13 P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA)
(3 more)
Metalloexopeptidase activity GO:0008235
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
13 P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA)
(3 more)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
13 P15034 (/IMP) P15034 (/IMP) P15034 (/IMP) P15034 (/IMP) P15034 (/IMP) P15034 (/IMP) P15034 (/IMP) P15034 (/IMP) P15034 (/IMP) P15034 (/IMP)
(3 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
13 P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI) P15034 (/IPI)
(3 more)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
2 F4HZG9 (/IMP) Q9NQH7 (/IMP)
Metallocarboxypeptidase activity GO:0004181
Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 P12955 (/TAS) P12955 (/TAS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2 Q11136 (/IDA) Q11136 (/IDA)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
1 B7ZMP1 (/ISO)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 F4HZG9 (/IMP)
Dipeptidyl-peptidase activity GO:0008239
Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.
1 Q9VG79 (/IDA)
Dipeptidase activity GO:0016805
Catalysis of the hydrolysis of a dipeptide.
1 Q96WX8 (/IDA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 Q9NQH7 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9NQH7 (/IPI)
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q9NQH7 (/IDA)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
17 Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS) Q48PQ9 (/ISS)
(7 more)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
3 A0A0G2KZA4 (/IMP) A9JT49 (/IMP) Q7SXT5 (/IMP)
Pancreas regeneration GO:1990798
The regrowth of a destroyed pancreas.
3 A0A0G2KZA4 (/IMP) A9JT49 (/IMP) Q7SXT5 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 Q9NQH7 (/IDA) Q9VG79 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 P12955 (/TAS) P12955 (/TAS)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
2 P12955 (/TAS) P12955 (/TAS)
Gastrulation GO:0007369
A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
2 A8KBZ9 (/IMP) Q6NYT0 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 Q9HTW6 (/IMP) Q9HTW6 (/IMP)
Glomerular filtration GO:0003094
The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
1 Q9NQH7 (/IMP)
Glomerular filtration GO:0003094
The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
1 B7ZMP1 (/ISO)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 F4HZG9 (/IGI)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 Q9NQH7 (/IMP)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 B7ZMP1 (/ISO)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 F4HZG9 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 P15034 (/HDA) P15034 (/HDA) P15034 (/HDA) P15034 (/HDA) P15034 (/HDA) P15034 (/HDA) P15034 (/HDA) P15034 (/HDA) P15034 (/HDA) P15034 (/HDA)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA) P15034 (/IDA)
(3 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 A0A140VJR2 (/IDA) A0A140VJR2 (/IDA) P12955 (/IDA) P12955 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 A0A140VJR2 (/IDA) A0A140VJR2 (/IDA) P12955 (/IDA) P12955 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 B7ZMP1 (/IDA) F4HZG9 (/IDA) Q9NQH7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q11136 (/ISO) Q11136 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q11136 (/ISO) Q11136 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P43590 (/HDA) P43590 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q38D78 (/IDA) Q9NQH7 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P12955 (/HDA) P12955 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 E9AF59 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 B7ZMP1 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 B7ZMP1 (/ISO)