The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Protein tyrosine phosphatase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1817
3D
3sr9A01 - 80.3
2
1741
3D
3sr9A02 - 89.0
3
1027 - - 87.1
4
853
3D
2nt2C00 - 94.5
5
798
3D
2c7sA00 - 65.7
6
675
3D
1oheA02 - 89.8
7
546
3D
1yfoB00 - 86.1
9
536
3D
2nz6A00 - 91.4
25
526
3D
6cwvA00 - 78.7
8
511 - - 92.9
10
489 - - 77.2
12
477
3D
5mmzB00 - 85.6
11
471
3D
1mkpA00 - 76.7
18
408
3D
6mddB03 - 78.7
13
369
3D
2nlkA02 - 92.3
16
363
3D
5h08A00 - 71.3
15
350
3D
3ezzF00 - 76.3
14
343 - - 63.4
17
339
3D
2qepB00 - 89.2
20
333
3D
6h8sA00 - 82.1
19
327 - - 63.4
21
303
3D
1p15B00 - 85.5
22
283
3D
2jjdF02 - 70.3
23
274
3D
4s0gA00 - 79.1
24
253
3D
2q47B00 - 84.5
26
241
3D
4iczA00 - 91.3
29
235
3D
5bzzD01 - 84.2
27
227 - - 79.2
28
227
3D
2oudA00 - 87.5
30
222
3D
2bzlA00 - 81.8
31
219
3D
1oheA01 - 59.6
32
214 - - 92.7
33
214
3D
1yguB01 - 71.7
34
180
3D
1wchA00 - 47.5
35
178 - - 98.2
36
177
3D
2r0bA00 - 96.6
37
176
3D
4hrfD00 - 88.4
45
174
3D
4j51B00 - 94.3
39
165
3D
2gjtB00 - 61.1
40
164
3D
2c46D00 - 91.2
38
162 - - 92.8
42
160
3D
1yguB02 - 92.1
41
157
3D
4ikcA00 - 60.0
43
150 - - 71.5
44
150
3D
4jmkB00 - 71.5
46
149
3D
1fq1A00 - 95.4
47
140 - - 73.9
48
137
3D
4wohA01 - 81.8
49
136
3D
2esbA00 - 82.3
50
Predicted
131
3D
4yr8H00 - 62.2
51
125 - - 80.8
52
120
3D
1yz4B01 - 87.3
53
113 - - 80.3
54
113
3D
4rkkC02 - 85.8
55
107 - - 77.2
56
102
3D
4ki9A00 - 93.7
59
100
3D
2pq5D00 - 42.0
57
98
3D
2g6zC00 - 72.1
60
94
3D
3rgqA00 - 93.3
58
92 - - 72.5
64
81
3D
4nyhC00 - 92.6
65
81
3D
3f81B00 - 64.2
63
80
3D
4ercB00 - 94.9
61
79 - - 56.8
62
77 - - 92.5
66
73 - - 73.9
67
71 - - 83.4
71
65
3D
4d3rA00 - 73.6
69
65
3D
4pyhA01 - 71.9
68
63 - - 75.6
70
61 - - 79.2
75
56
3D
4kyrA00 - 73.6
72
56 - - 61.1
74
55 - - 55.2
73
55 - - 78.6
76
54 - - 74.8
77
53 - - 38.0
78
52 - - 66.8
79
51 - - 76.8
80
45 - - 92.6
81
44 - - 71.6
82
42 - - 94.0
86
42
3D
3s4oB00 - 92.1
85
41 - - 76.7
84
41 - - 88.6
83
41 - - 77.9
87
39 - - 39.2
88
39 - - 87.6
89
36 - - 19.9
90
35 - - 81.6
94
32
3D
2j17B00 - 79.6
91
31 - - 52.3
92
31 - - 83.0
93
30 - - 71.0
96
27 - - 75.3
95
27 - - 79.1
98
26 - - 86.4
107
26
3D
5y16B00 - 83.0
97
26 - - 70.6
99
25 - - 62.7
105
24
3D
5tsrC00 - 24.0
100
24 - - 71.7
101
23 - - 76.1
157
23
3D
5z5bC00 - 93.6
102
23 - - 96.2
103
23 - - 67.0
104
22 - - 78.9
106
21 - - 78.7
108
20 - - 20.9
109
19 - - 74.2
110
18 - - 75.5
112
17 - - 73.8
111
17 - - 73.6
113
17 - - 15.4
114
17 - - 88.0
116
16 - - 80.7
117
16 - - 79.7
115
16 - - 81.2
120
15 - - 84.2
121
15 - - 80.2
119
15 - - 55.6
118
15 - - 86.4
124
14 - - 19.1
122
14 - - 58.9
123
14 - - 86.8
127
13 - - 78.3
125
13 - - 8.8
126
13 - - 75.7
128
12 - - 88.9
132
12 - - 47.0
129
12 - - 83.7
131
12 - - 66.0
130
12 - - 94.9
133
12 - - 83.3
136
11 - - 9.7
137
11 - - 1.6
142
Pyp1
11 - - 76.9
147
11 - - 36.6
149
11 - - 97.6
139
11 - - 12.2
135
11 - - 19.8
145
11 - - 96.3
148
11 - - 82.3
141
11 - - 42.6
146
11 - - 87.6
144
11 - - 75.0
138
11 - - 6.8
140
11 - - 10.8
143
11 - - 34.2
134
11 - - 87.2
152
10 - - 67.5
151
10 - - 44.3
150
10 - - 81.9
153
9 - - 0.6
155
9 - - 10.1
154
9 - - 9.3
158
9 - - 33.5
156
9 - - 35.3
184
8
3D
3emuA00 - 15.9
165
8 - - 20.8
161
8 - - 86.7
188
8
3D
1v3aA00 - 52.0
164
8 - - 8.9
160
8 - - 36.4
177
8
3D
4r0sA00 - 2.9
163
8 - - 13.9
159
8 - - 18.8
162
8 - - 9.2
166
8 - - 5.0
180
7 - - 7.9
170
7 - - 21.1
175
7 - - 9.8
181
7 - - 11.9
168
7 - - 12.8
178
7 - - 8.9
174
7 - - 5.4
183
7 - - 15.4
179
7 - - 6.8
182
7 - - 11.4
167
7 - - 39.9
186
7 - - 71.9
173
7 - - 7.8
171
7 - - 2.4
176
7 - - 2.8
169
7 - - 0.0
172
7 - - 7.8
185
7 - - 88.1
191
6 - - 64.3
187
6 - - 72.5
207
6 - - 3.8
198
6 - - 0.7
202
6 - - 30.1
247
6
3D
3m4uB00 - 0.0
209
6 - - 81.3
210
6 - - 68.5
200
AFU_orthologue AFUA_2G02760
6 - - 16.1
192
6 - - 73.9
199
6 - - 5.5
195
6 - - 3.0
203
6 - - 1.6
204
6 - - 30.5
211
6 - - 45.5
193
6 - - 77.0
189
6 - - 71.2
205
6 - - 49.5
196
6 - - 3.3
206
6 - - 2.8
194
6 - - 5.4
197
6 - - 0.7
208
6 - - 52.4
201
6 - - 19.4
190
6 - - 71.5
212
5 - - 81.6
232
5 - - 39.2
225
5 - - 13.2
229
5 - - 70.5
222
5 - - 10.8
217
5 - - 79.0
213
5 - - 83.2
224
5 - - 66.7
233
5 - - 91.2
228
5 - - 81.0
218
5 - - 0.0
221
5 - - 4.8
227
5 - - 64.2
255
5
3D
3n0aA01 - 23.4
230
5 - - 81.4
214
5 - - 77.6
219
5 - - 9.8
220
5 - - 12.7
226
5 - - 78.7
215
AFU_orthologue AFUA_6G06650
5 - - 72.8
231
5 - - 83.1
223
5 - - 9.4
216
5 - - 82.5
246
4 - - 10.8
272
4 - - 66.9
262
4 - - 84.5
257
4 - - 7.2
252
4 - - 2.8
271
4 - - 41.4
242
4 - - 54.4
254
4 - - 39.7
263
4 - - 71.6
267
4 - - 42.2
243
4 - - 65.5
268
4 - - 66.1
238
4 - - 63.5
253
4 - - 17.3
258
4 - - 73.9
248
4 - - 14.6
236
4 - - 38.5
234
4 - - 14.6
260
4 - - 33.0
264
4 - - 56.1
250
4 - - 24.9
259
4 - - 58.4
249
4 - - 74.5
240
4 - - 24.5
239
4 - - 39.8
269
4 - - 55.7
244
4 - - 29.8
237
4 - - 56.1
235
4 - - 74.4
265
4 - - 77.4
251
4 - - 10.8
256
4 - - 86.5
245
4 - - 12.8
241
4 - - 26.4
270
4 - - 91.7
266
4 - - 81.1
261
4 - - 40.4
285
3 - - 1.7
301
3 - - 8.5
294
3 - - 66.5
278
3 - - 60.5
299
3 - - 4.3
305
3 - - 73.5
281
3 - - 3.1
284
3 - - 13.2
289
3 - - 6.0
290
3 - - 5.3
279
3 - - 7.0
293
3 - - 9.1
280
3 - - 0.0
273
3 - - 70.8
302
3 - - 45.7
298
3 - - 0.0
288
3 - - 68.9
287
3 - - 4.8
274
3 - - 18.4
303
3 - - 68.0
276
3 - - 56.9
297
3 - - 0.0
283
3 - - 1.6
295
3 - - 6.7
300
Hsp40
3 - - 0.0
286
3 - - 9.0
296
3 - - 2.9
275
3 - - 34.4
292
3 - - 11.0
291
3 - - 0.0
282
3 - - 0.7
277
3 - - 61.4
304
3 - - 70.4
306
3 - - 81.1
350
2 - - 6.7
340
2 - - 0.0
311
2 - - 29.6
391
2 - - 0.7
308
2 - - 33.6
366
2 - - 38.7
349
2 - - 3.6
323
2 - - 35.9
359
2 - - 21.1
330
2 - - 9.9
360
2 - - 32.9
353
2 - - 0.0
375
2 - - 2.9
387
2 - - 8.9
395
2 - - 3.6
361
2 - - 34.4
307
2 - - 16.5
326
2 - - 0.0
335
2 - - 0.0
315
2 - - 36.1
317
2 - - 13.4
319
2 - - 37.5
344
2 - - 0.0
336
2 - - 1.4
383
2 - - 39.8
406
2 - - 40.6
365
2 - - 39.6
408
2 - - 47.3
382
2 - - 0.0
367
2 - - 4.0
351
2 - - 1.9
342
AFU_orthologue AFUA_1G13040
2 - - 0.0
341
2 - - 0.0
405
2 - - 39.0
309
2 - - 23.0
392
2 - - 4.0
399
2 - - 37.0
386
2 - - 29.8
329
2 - - 0.0
346
2 - - 0.0
372
2 - - 7.5
322
2 - - 41.0
310
2 - - 30.1
354
2 - - 2.9
316
2 - - 29.3
314
2 - - 12.2
355
2 - - 0.0
334
2 - - 7.3
402
2 - - 9.8
362
2 - - 34.0
407
2 - - 43.7
376
2 - - 0.0
371
2 - - 0.0
339
2 - - 0.0
345
2 - - 0.0
396
2 - - 0.0
318
2 - - 39.5
356
2 - - 7.2
378
2 - - 0.0
325
2 - - 13.1
337
2 - - 2.9
389
2 - - 8.0
410
2 - - 37.9
381
2 - - 0.0
373
2 - - 0.0
400
2 - - 37.8
333
2 - - 0.0
393
2 - - 0.0
347
2 - - 0.0
320
2 - - 42.9
385
2 - - 21.4
377
2 - - 0.0
338
2 - - 0.0
328
2 - - 2.9
363
2 - - 39.2
313
2 - - 15.4
397
2 - - 0.0
401
2 - - 30.9
404
2 - - 38.5
357
2 - - 15.5
390
2 - - 7.1
358
2 - - 20.1
331
2 - - 0.4
348
2 - - 0.0
388
2 - - 0.7
364
2 - - 32.6
324
2 - - 13.3
379
2 - - 0.0
312
2 - - 35.7
370
2 - - 2.5
380
2 - - 0.0
352
2 - - 8.9
369
2 - - 0.5
394
2 - - 0.0
332
2 - - 0.0
368
2 - - 0.4
374
2 - - 0.0
409
2 - - 46.4
327
2 - - 0.0
411
2 - - 37.6
398
2 - - 1.7
384
2 - - 0.9
343
2 - - 0.0
321
2 - - 38.4
403
2 - - 36.4
512
1 - - 0.0
463
1 - - 0.0
458
1 - - 0.0
517
1 - - 0.0
495
1 - - 0.0
486
1 - - 0.0
569
1 - - 0.0
536
1 - - 0.0
444
1 - - 0.0
508
1 - - 0.0
558
1 - - 0.0
573
1 - - 0.0
506
1 - - 0.0
581
1 - - 0.0
456
1 - - 0.0
468
1 - - 0.0
413
1 - - 0.0
606
1 - - 0.0
432
1 - - 0.0
545
1 - - 0.0
588
1 - - 0.0
542
1 - - 0.0
574
1 - - 0.0
526
1 - - 0.0
566
1 - - 0.0
604
1 - - 0.0
477
1 - - 0.0
449
1 - - 0.0
501
1 - - 0.0
490
1 - - 0.0
461
1 - - 0.0
425
1 - - 0.0
539
1 - - 0.0
520
1 - - 0.0
532
1 - - 0.0
584
1 - - 0.0
412
1 - - 0.0
554
1 - - 0.0
552
1 - - 0.0
440
1 - - 0.0
467
1 - - 0.0
474
1 - - 0.0
481
1 - - 0.0
563
1 - - 0.0
472
1 - - 0.0
546
1 - - 0.0
537
1 - - 0.0
529
1 - - 0.0
600
1 - - 0.0
457
1 - - 0.0
505
1 - - 0.0
419
1 - - 0.0
570
1 - - 0.0
421
1 - - 0.0
491
1 - - 0.0
597
1 - - 0.0
559
1 - - 0.0
443
1 - - 0.0
580
1 - - 0.0
431
1 - - 0.0
509
1 - - 0.0
523
1 - - 0.0
453
1 - - 0.0
595
1 - - 0.0
488
1 - - 0.0
507
1 - - 0.0
436
1 - - 0.0
568
1 - - 0.0
525
1 - - 0.0
427
1 - - 0.0
426
1 - - 0.0
498
1 - - 0.0
483
1 - - 0.0
533
1 - - 0.0
462
1 - - 0.0
414
1 - - 0.0
615
1 - - 0.0
476
1 - - 0.0
469
1 - - 0.0
575
1 - - 0.0
543
1 - - 0.0
603
1 - - 0.0
565
1 - - 0.0
511
1 - - 0.0
471
1 - - 0.0
502
1 - - 0.0
553
1 - - 0.0
555
1 - - 0.0
423
1 - - 0.0
422
1 - - 0.0
593
1 - - 0.0
616
1 - - 0.0
464
1 - - 0.0
562
1 - - 0.0
439
1 - - 0.0
599
1 - - 0.0
587
1 - - 0.0
609
1 - - 0.0
624
1 - - 0.0
435
1 - - 0.0
596
1 - - 0.0
613
1 - - 0.0
494
1 - - 0.0
487
1 - - 0.0
448
1 - - 0.0
547
1 - - 0.0
482
1 - - 0.0
499
1 - - 0.0
450
1 - - 0.0
473
1 - - 0.0
528
1 - - 0.0
560
1 - - 0.0
451
1 - - 0.0
454
1 - - 0.0
578
1 - - 0.0
540
1 - - 0.0
571
1 - - 0.0
594
1 - - 0.0
586
1 - - 0.0
430
1 - - 0.0
447
1 - - 0.0
415
1 - - 0.0
480
1 - - 0.0
438
1 - - 0.0
417
1 - - 0.0
493
1 - - 0.0
534
1 - - 0.0
475
1 - - 0.0
515
1 - - 0.0
519
1 - - 0.0
446
1 - - 0.0
556
1 - - 0.0
510
1 - - 0.0
549
1 - - 0.0
614
Hsp40
1 - - 0.0
583
1 - - 0.0
591
1 - - 0.0
424
1 - - 0.0
434
1 - - 0.0
442
1 - - 0.0
465
1 - - 0.0
479
1 - - 0.0
619
1 - - 0.0
621
1 - - 0.0
524
1 - - 0.0
598
1 - - 0.0
602
1 - - 0.0
612
1 - - 0.0
564
1 - - 0.0
503
1 - - 0.0
576
1 - - 0.0
484
1 - - 0.0
544
1 - - 0.0
623
1 - - 0.0
608
1 - - 0.0
522
1 - - 0.0
459
1 - - 0.0
516
1 - - 0.0
561
1 - - 0.0
455
1 - - 0.0
550
1 - - 0.0
592
1 - - 0.0
530
1 - - 0.0
470
1 - - 0.0
437
1 - - 0.0
572
1 - - 0.0
527
1 - - 0.0
548
1 - - 0.0
418
1 - - 0.0
485
1 - - 0.0
460
1 - - 0.0
452
1 - - 0.0
579
1 - - 0.0
535
1 - - 0.0
541
1 - - 0.0
567
1 - - 0.0
416
1 - - 0.0
496
1 - - 0.0
605
1 - - 0.0
607
1 - - 0.0
445
1 - - 0.0
582
1 - - 0.0
557
1 - - 0.0
441
1 - - 0.0
590
1 - - 0.0
617
1 - - 0.0
428
1 - - 0.0
500
1 - - 0.0
514
1 - - 0.0
610
1 - - 0.0
513
1 - - 0.0
589
1 - - 0.0
620
1 - - 0.0
611
1 - - 0.0
492
1 - - 0.0
429
1 - - 0.0
489
1 - - 0.0
585
1 - - 0.0
622
1 - - 0.0
538
1 - - 0.0
521
1 - - 0.0
433
1 - - 0.0
518
1 - - 0.0
497
1 - - 0.0
478
1 - - 0.0
601
1 - - 0.0
551
1 - - 0.0
504
1 - - 0.0
531
1 - - 0.0
420
1 - - 0.0
577
1 - - 0.0
466
1 - - 0.0
618
1 - - 0.0