The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aspartate Aminotransferase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 39: Serine--pyruvate aminotransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 25 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
10 Q482V2 (/ISS) Q482V2 (/ISS) Q9KUW7 (/ISS) Q9KUW7 (/ISS) Q9KUW7 (/ISS) Q9KUW7 (/ISS) Q9KUW7 (/ISS) Q9KUW7 (/ISS) Q9KUW7 (/ISS) Q9KUW7 (/ISS)
Alanine-glyoxylate transaminase activity GO:0008453
Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.
6 O35423 (/ISS) P31029 (/ISS) P31030 (/ISS) P41689 (/ISS) Q54GT6 (/ISS) Q5RDP0 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 O35423 (/ISS) P09139 (/ISS) P31029 (/ISS) P31030 (/ISS) P41689 (/ISS) Q5RDP0 (/ISS)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
6 O35423 (/ISS) P09139 (/ISS) P31029 (/ISS) P31030 (/ISS) P41689 (/ISS) Q5RDP0 (/ISS)
Alanine-glyoxylate transaminase activity GO:0008453
Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.
3 P09139 (/IDA) P21549 (/IDA) Q9W3Z3 (/IDA)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
2 P09139 (/IDA) P21549 (/IDA)
Serine-pyruvate transaminase activity GO:0004760
Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
1 P09139 (/IDA)
Serine-pyruvate transaminase activity GO:0004760
Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
1 O35423 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 O35423 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P21549 (/IPI)
Alanine-glyoxylate transaminase activity GO:0008453
Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.
1 O35423 (/IMP)
Alanine-glyoxylate transaminase activity GO:0008453
Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.
1 O35423 (/ISO)
Alanine-glyoxylate transaminase activity GO:0008453
Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.
1 P21549 (/TAS)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 P21549 (/IDA)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 O35423 (/ISO)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
1 O35423 (/ISO)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 P21549 (/IDA)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 P21549 (/IMP)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 O35423 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P21549 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O35423 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P21549 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 O35423 (/ISO)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 P21549 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 O35423 (/ISO)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glyoxylate catabolic process GO:0009436
The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.
2 P21549 (/IDA) Q9W3Z3 (/IDA)
Glycine biosynthetic process, by transamination of glyoxylate GO:0019265
The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate.
2 P09139 (/IDA) P21549 (/IDA)
Glyoxylate metabolic process GO:0046487
The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
2 O35423 (/IMP) P21549 (/IMP)
Cellular response to estrogen stimulus GO:0071391
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
2 Q6NWD0 (/IDA) Q6PHK4 (/IDA)
Protein targeting to peroxisome GO:0006625
The process of directing proteins towards the peroxisome, usually using signals contained within the protein.
1 P21549 (/TAS)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O35423 (/IDA)
Glyoxylate catabolic process GO:0009436
The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.
1 O35423 (/ISO)
Glycine biosynthetic process, by transamination of glyoxylate GO:0019265
The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate.
1 O35423 (/ISO)
L-cysteine catabolic process GO:0019448
The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.
1 P21549 (/IDA)
L-cysteine catabolic process GO:0019448
The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.
1 O35423 (/ISO)
Cellular nitrogen compound metabolic process GO:0034641
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
1 P21549 (/TAS)
L-alanine catabolic process GO:0042853
The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
1 P21549 (/IDA)
L-alanine catabolic process GO:0042853
The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
1 O35423 (/ISO)
Pyruvate biosynthetic process GO:0042866
The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.
1 P09139 (/IDA)
Pyruvate biosynthetic process GO:0042866
The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.
1 O35423 (/ISO)
Glyoxylate metabolic process GO:0046487
The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
1 O35423 (/ISO)
Glyoxylate metabolic process GO:0046487
The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
1 Q54GT6 (/ISS)
Oxalic acid secretion GO:0046724
The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue.
1 O35423 (/IMP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P09139 (/IDA)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 O35423 (/ISO)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 P09139 (/IDA)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 O35423 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 O35423 (/TAS) P09139 (/TAS) P41689 (/TAS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
3 O35423 (/TAS) P09139 (/TAS) P41689 (/TAS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 P09139 (/IDA) P21549 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P09139 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O35423 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P09139 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 O35423 (/ISO)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q9W3Z3 (/ISM)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 O35423 (/ISO)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q9W3Z3 (/ISS)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
1 P21549 (/IDA)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
1 O35423 (/ISO)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
1 P21549 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P21549 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P21549 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 O35423 (/ISO)