The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PPM-type phosphatase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 54: Protein phosphatase type 2C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
9 P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P35182 (/IPI) P35182 (/IPI) P35182 (/IPI) P35182 (/IPI) P35182 (/IPI) P35182 (/IPI) P35182 (/IPI) P35182 (/IPI) P35182 (/IPI)
MAP kinase serine/threonine phosphatase activity GO:1990439
Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate.
9 P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
2 A0A1D8PEN6 (/ISA) A0A1D8PEN6 (/ISA)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion inheritance GO:0000001
The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton.
9 P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
9 P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
9 P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
9 P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP)
Pheromone-dependent signal transduction involved in conjugation with cellular fusion GO:0000750
A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
9 P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP)
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
9 P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
9 P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
9 P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA)
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
9 P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI)
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
9 P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP) P35182 (/IMP)
Inactivation of MAPKK activity GO:0051389
Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK).
9 P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI) P35182 (/IGI)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 A0A1D8PEN6 (/IMP) A0A1D8PEN6 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 A0A1D8PEN6 (/IMP) A0A1D8PEN6 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
2 A0A1D8PEN6 (/IMP) A0A1D8PEN6 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA) P35182 (/IDA)