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CATH Superfamily 3.60.20.10

Aminohydrolase, N-terminal nucleophile (Ntn) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: Proteasome subunit beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 15 P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI)
(5 more)
Threonine-type endopeptidase activity GO:0004298
Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
 14 P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA)
(4 more)
Threonine-type endopeptidase activity GO:0004298
Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
 14 P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP)
(4 more)
Zymogen binding GO:0035375
Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.
 14 P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI) P9WHT9 (/IPI)
(4 more)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
 7 Q53079 (/IDA) Q53083 (/IDA) Q53083 (/IDA) Q53083 (/IDA) Q53083 (/IDA) Q53083 (/IDA) Q53083 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
 21 P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA)
(11 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
 14 P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA)
(4 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
 14 P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP)
(4 more)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
 14 P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP) P9WHT9 (/IMP)
(4 more)
Modification-dependent protein catabolic process GO:0019941
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.
 14 P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA)
(4 more)
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
 14 P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA)
(4 more)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteasome core complex, beta-subunit complex GO:0019774
The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.
 21 P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA)
(11 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
 14 P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA)
(4 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
 14 P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA) P9WHT9 (/IDA)
(4 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 14 P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA) P9WHT9 (/HDA)
(4 more)
Proteasome core complex, beta-subunit complex GO:0019774
The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.
 4 A0QZ47 (/ISS) A0QZ47 (/ISS) A0QZ47 (/ISS) Q7AKQ5 (/ISS)